Difference between revisions of "DASworkshop200802:spice"

From BioDAS
Jump to: navigation, search
(SPICE)
(Pfam)
Line 23: Line 23:
  
 
notice how the PFAM track is on top of the UniProt display.
 
notice how the PFAM track is on top of the UniProt display.
map the PFAM domains on the structure.
+
map the PFAM domains on the structure.  
 +
 
 +
Do the PFAM domains correspond to what you would consider structural domains?
 +
 
 +
What could the Pfam-B domain be?
  
 
==A multiple structure alignment viewer==
 
==A multiple structure alignment viewer==

Revision as of 13:40, 24 February 2008

SPICE

a browser for protein sequences, structures and their annotations

There are various ways to launch SPICE.

Ensembl

The PDB_Spice DAS track in the Ensembl protview and contigviews allows to show protein structure mappings/

e.g. http://www.ensembl.org/Homo_sapiens/protview?peptide=ENSP00000365116

enable the track in this view and click on the track and then again on the protein structure image. This allows you to launch SPICE.

Pfam

SPICE can be easily linked to from external web sites.

Find the protein structure 1cdg in Pfam: http://pfam.sanger.ac.uk/structure?entry=1cdg&type=Structure

click on view structure and select SPICE again.

notice how the PFAM track is on top of the UniProt display. map the PFAM domains on the structure.

Do the PFAM domains correspond to what you would consider structural domains?

What could the Pfam-B domain be?

A multiple structure alignment viewer

CASP 7 results

The CASP 7 - target view allows to launch SPICE again

white... solved target. others: predictions for various targets. sort predictions by score switch between sequence based on structure based alignment algorithms.